Journal article
Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established population of genotype 2.1.7 sensitive to antimicrobials
ZA Dyson, E Malau, PF Horwood, R Ford, V Siba, M Yoannes, W Pomat, M Passey, LM Judd, DJ Ingle, DA Williamson, G Dougan, AR Greenhill, KE Holt
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2022
Abstract
Background Typhoid fever, a systemic infection caused by Salmonella enterica serovar Typhi, remains a considerable public health threat in impoverished regions within many low-and middle-income settings. However, we still lack a detailed understanding of the emergence, population structure, molecular mechanisms of antimicrobial resistance (AMR), and transmission dynamics of S. Typhi across many settings, particularly throughout the Asia-Pacific islands. Here we present a comprehensive whole genome sequence (WGS) based overview of S. Typhi populations circulating in Papua New Guinea (PNG) over 30 years. Principle findings Bioinformatic analysis of 86 S. Typhi isolates collected between 1980–2..
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Awarded by Horizon 2020 Framework Programme
Funding Acknowledgements
KEH was supported by a grant funded by the Wellcome Trust (STRATAA; 106158/Z/14/Z) to employ ZAD, and received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement TyphiNET (#845681). DJI was supported by a National Health and Medical Research Council (NHMRC) Emerging Leadership Fellowship (GNT1195210). DAW is supported by an NHMRC Emerging Leadership Fellowship (GNT1174555). KEH was supported by a Senior Medical Research Fellowship from the Viertel Foundation of Australia, and the Bill and Melinda Gates Foundation, Seattle (grant #OPP1175797). This work was supported, in whole or in part, by the Bill & Melinda Gates Foundation [OPP1175797]. Under the grant conditions of the Foundation, a Creative Commons Attribution 4.0 Generic License has already been assigned to the Author Accepted Manuscript version that might arise from this submission. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.